Greenville vs Spartanburg: Nurse Practitioner Salary (2026)
Compare nurse practitioner salaries between Greenville, SC and Spartanburg, SC. All figures are 2026 estimates projected from BLS 2025 data.
Side-by-Side Comparison
| Metric | Greenville, SC | Spartanburg, SC |
|---|---|---|
| Median Salary | $123,395 | $125,299▲ |
| Hourly Rate | $59.33 | $60.24▲ |
| Entry Level (P10) | $84,736 | $106,833▲ |
| 25th Percentile | $113,826▲ | $113,123 |
| 75th Percentile | $134,382 | $136,751▲ |
| Top Earner (P90) | $150,592 | $162,251▲ |
| Total Employed | 1,120▲ | 260 |
Verdict
Spartanburg, SC offers better overall compensation for nurse practitioners, winning 3 out of 4 metrics compared to Greenville.
The salary gap between Greenville and Spartanburg is $1,904 (1.54%). Spartanburg's median is -8.45% compared to the US national median of $136,864.
Salary Range Comparison
The full salary range (10th to 90th percentile) in Greenville spans $65,856,Spartanburg spans $55,418. Greenville has a wider pay range, meaning more potential for high earners but also more variation.
Cost-of-Living Adjusted Comparison
After cost-of-living adjustment, Spartanburg ($137,614 effective) pays 4.01% more than Greenville ($132,313 effective).
Cost-of-living adjustment: salary × (100 / CoL index). Index of 100 = national average.
Which City Is Right for You?
Choose Greenville if…
- ✓Larger job market (1,120 employed)
- ✓You prefer the South Carolina area and lifestyle
Choose Spartanburg if…
- ✓Higher median salary ($125,299/year)
- ✓Better top-earner potential ($162,251)
- ✓Better purchasing power (CoL-adjusted: $137,614)
- ✓You prefer the South Carolina area and lifestyle
Historical Salary Growth Comparison
Based on BLS OEWS metropolitan area data, nurse practitioner salaries in Greenville grew 25.7% from 2019 to 2025, compared to 21.9% growth in Spartanburg over the same period.
Greenville, SC
$94,930 (2019) → $119,280 (2025)
Spartanburg, SC
$99,340 (2019) → $121,120 (2025)
View Full Salary Data
Greenville, SC
Spartanburg, SC
Frequently Asked Questions
Which city pays nurse practitioners more: Greenville or Spartanburg?
What is the hourly rate difference between Greenville and Spartanburg?
Should I relocate from Greenville to Spartanburg as a nurse practitioner?
What do entry-level nurse practitioners earn in Greenville vs Spartanburg?
Written by Maria Gonzalez, MSN, NP-C
Career Analyst
Maria has 10 years of experience in adult healthcare. She works in a community health clinic. Her specialty is chronic disease management.
Methodology & Data Source
All salary figures are 2026 projections based on BLS OEWS May 2025 data. A 3.45% CAGR (derived from 6-year national BLS trends) was applied to estimate current compensation. Cost-of-living adjustments use BEA Regional Price Parity data. Actual salaries vary by employer, certifications, and experience.
Data Sources & Methodology
Source: BLS, OEWS , released .
Compiled and verified by Maria Gonzalez, MSN, NP-C, a licensed nurse practitioner with 10+ years of clinical experience. · View source data at BLS.gov