Des Moines vs Sioux City: Nurse Practitioner Salary (2026)
Compare nurse practitioner salaries between Des Moines, IA and Sioux City, IA. All figures are 2026 estimates projected from BLS 2025 data.
Side-by-Side Comparison
| Metric | Des Moines, IA | Sioux City, IA |
|---|---|---|
| Median Salary | $136,792▲ | $133,513 |
| Hourly Rate | $65.76▲ | $64.19 |
| Entry Level (P10) | $117,385▲ | $110,433 |
| 25th Percentile | $132,530▲ | $124,088 |
| 75th Percentile | $146,847 | $147,758▲ |
| Top Earner (P90) | $172,720▲ | $168,148 |
| Total Employed | 820▲ | 150 |
Verdict
Des Moines, IA offers better overall compensation for nurse practitioners, winning 4 out of 4 metrics compared to Sioux City.
The salary gap between Des Moines and Sioux City is $3,279 (2.46%). Des Moines's median is -0.05% compared to the US national median of $136,864.
Salary Range Comparison
The full salary range (10th to 90th percentile) in Des Moines spans $55,335,Sioux City spans $57,715. Sioux City has a wider pay range, suggesting more variation in pay between entry-level and experienced nurse practitioners.
Cost-of-Living Adjusted Comparison
After cost-of-living adjustment, Sioux City ($154,432 effective) pays 3.53% more than Des Moines ($149,172 effective).
Cost-of-living adjustment: salary × (100 / CoL index). Index of 100 = national average.
Which City Is Right for You?
Choose Des Moines if…
- ✓Higher median salary ($136,792/year)
- ✓Better top-earner potential ($172,720)
- ✓Larger job market (820 employed)
- ✓You prefer the Iowa area and lifestyle
Choose Sioux City if…
- ✓Better purchasing power (CoL-adjusted: $154,432)
- ✓You prefer the Iowa area and lifestyle
Historical Salary Growth Comparison
Based on BLS OEWS metropolitan area data, nurse practitioner salaries in Des Moines grew 32.5% from 2019 to 2025, compared to 19.3% growth in Sioux City over the same period.
Des Moines, IA
$99,770 (2019) → $132,230 (2025)
Sioux City, IA
$108,160 (2019) → $129,060 (2025)
View Full Salary Data
Des Moines, IA
Sioux City, IA
Frequently Asked Questions
Which city pays nurse practitioners more: Des Moines or Sioux City?
What is the hourly rate difference between Des Moines and Sioux City?
Should I relocate from Des Moines to Sioux City as a nurse practitioner?
What do entry-level nurse practitioners earn in Des Moines vs Sioux City?
Written by Maria Gonzalez, MSN, NP-C
Career Analyst
Maria has 10 years of experience in adult healthcare. She works in a community health clinic. Her specialty is chronic disease management.
Methodology & Data Source
All salary figures are 2026 projections based on BLS OEWS May 2025 data. A 3.45% CAGR (derived from 6-year national BLS trends) was applied to estimate current compensation. Cost-of-living adjustments use BEA Regional Price Parity data. Actual salaries vary by employer, certifications, and experience.
Data Sources & Methodology
Source: BLS, OEWS , released .
Compiled and verified by Maria Gonzalez, MSN, NP-C, a licensed nurse practitioner with 10+ years of clinical experience. · View source data at BLS.gov